Poor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants.
نویسندگان
چکیده
Administration of oral indomethacin to treat cardiorespiratory failure in 7 low birthweight infants, after failure of conventional therapy, produced an improvement in only 2 infants. These infants had a higher birthweight than the group as a whole. Surgical ligation, rather than oral indomethacin, may be the treatment of choice for persistent ductus arteriosus in very low birthweight infants.
منابع مشابه
Indomethacin treatment for patent ductus arteriosus in very low birthweight infants: double blind trial.
Thirty very low birthweight (VLBW) infants (mean gestational age 28.9 weeks; mean birthweight 1138 g) with symptomatic patent ductus arteriosus (PDA) were entered in a randomised double blind trial of indomethacin treatment. The mean age at diagnosis was 7.6 days and at entry to the trial 10.7 days. Before treatment for PDA the indomethacin and placebo groups were well matched for gestational a...
متن کاملUse of indomethacin and its relationship to retinopathy of prematurity in very low birthweight infants.
The relationship between the use of indomethacin, a prostaglandin inhibitor, for closure of patent ductus arteriosus (PDA) and the occurrence of retinopathy of prematurity was investigated retrospectively. 63 preterm infants less than or equal to 1500 g who were less than or equal to 32 weeks' gestational age, appropriate weight for gestational age, with a diagnosis of PDA, and admitted during ...
متن کاملPatent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study.
BACKGROUND Patent ductus arteriosus is a risk factor for the development of necrotizing enterocolitis. The use of indomethacin to treat patent ductus arteriosus in preterm infants may either decrease the incidence of necrotizing enterocolitis by stabilizing or closing the ductus arteriosus or increase its incidence by a direct constricting effect on mesenteric blood vessels. The authors sought ...
متن کاملPatent ductus arteriosus in infants <29 weeks gestation--outcomes and factors affecting closure.
OBJECTIVE To determine Patent ductus arteriosus (PDA) closure rates for extremely preterm infants in a tertiary care centre, factors affecting response to indomethacin and outcomes of these infants relative to their PDA status. SETTING Neonatal intensive care unit in tertiary-care children's hospital. DESIGN Retrospective medical record review. METHODS A retrospective chart review of all ...
متن کاملFailure of indomethacin to close persistent ductus arteriosus in infants weighing under 1000 grams.
Six preterm infants with a persistent ductus arteriosus, who failed to improve with conventional medical management, received indomethacin in an attempt to close the duct pharmacologically. All infants weighed less than 1000 g when the drug was administered. All showed a transient response to indomethacin; however, no infant demonstrated a permanent response, even though 5 of the 6 received mul...
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ورودعنوان ژورنال:
- British heart journal
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1979